Figure 1. Measures of clinical toxicity. (A) Percentage of rats with grade 0, 1, 2, and 3 diarrhea between 6 and 120 h following irinotecan (175 mg/kg ip) administration. (B) Percentage change in weight from baseline to 120 h in rats following vehicle control (sorbitol/lactic acid buffer: 45 mg/mL sorbitol/0.9 mg/mL lactic acid, pH 3.4) or irinotecan (175 mg/kg ip). *P < 0.01 vs. 120 h, **P < 0.0001 vs. 24 h and 120 h. A one-way analysis of variance with Tukey’s post hoc was performed to determine significance (n = 39).