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. Author manuscript; available in PMC: 2014 Feb 18.
Published in final edited form as: ACS Chem Biol. 2013 Oct 16;8(12):2785–2793. doi: 10.1021/cb400607h

Figure 7. CaCrg1 is important for C. albicans virulence in Galleria mellonella.

Figure 7

A. Kaplan-Meier survival plot demonstrating that the deletion of CaCRG1 results in increased survival (relative to wt) of G. mellonella larvae injected with C. albicans.

B. A model demonstrating how CaCrg1 and it functional interactions play a role in drug response and fungal virulence . CaCrg1 interacts with toxic cantharidin that inhibits protein phosphatases involved in multiple biological processes. Upon the drug exposure CaCRG1 maintains membrane trafficking, adhesion and hyphal elongation, the processes required for fungal virulence.