Table 2. Mouse strains, groups, and numbers in this study*.
Sham | H. pylori (Hp)-infected | |||
---|---|---|---|---|
Female | Male | Female | Male | |
C3B6F1† | 4 (4) | 2 (4) | 4 (5) | 6 (7) |
C3B6F1-Tg(Alb1-HCVN)35Sml‡ | 3 (4) | 6 (6) | 9 (10) | 10 (12) |
Number in parentheses indicates number of mice at the initiation of the study. One WT male mouse was euthanized at ~6 mo postinoculation and another mouse in this group was diagnosed with osteosarcoma at the end of the study. One WT female Hp mouse was diagnosed with histiocytic sarcoma at the end of the study. One WT male Hp mouse was found dead at ~12 mo postinoculation. Two HT male Hp mice were euthanized at ~3 to 4 mo and ~4 mo postinoculation, respectively. The three mice euthanized before the end of the study did not exhibit preneoplastic and/or neoplastic liver lesions. One HT female and one HT female Hp mouse were diagnosed with lymphoma at the end of the study. The mice with other tumors (osteosarcoma, histiocytic sarcoma, and lymphoma) and the mice that were euthanized or died before the end of the study were not included in the final analyses. † Wild-type (WT); ‡, HCV transgenic (HT).