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. 2014 Feb 18;9(2):e88811. doi: 10.1371/journal.pone.0088811

Figure 2. Developmental defects in Meteorin−/− embryos during gastrulation.

Figure 2

(A, B) Gross morphology of Meteorin+/+ and Meteorin−/− embryos at E7.5. A fraction of Meteorin−/− embryos survived at E7.5 and these were markedly smaller than Meteorin+/+ embryos. (C) A schematic view indicates where the transverse section images of panels F and G were obtained. (D–K) Paraffin sections of each decidua from Meteorin heterozygous matings were stained with hematoxylin and eosin. At E7.0, slightly thickened cell layers were observed in the presumptive primitive streak in abnormal embryos (E and I) and this accumulation of cells became more apparent at E7.25 (I). At E7.5, some embryos were resorbed and were no longer seen in deciduae (K). All scale bars: 100 µm.