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. 2014 Feb 18;9(2):e88868. doi: 10.1371/journal.pone.0088868

Table 1. Description of Experimental BMT Model.

Donor Strain Recipient Strain Mismatch Type Conditioning Regimen Major T-cell Type Cell Type & Dosage
Model 1. GVHD with Conditioning Regimen
Syngeneic (Syn) C57/Bl6(Thy1.1: H-2b) C57/Bl6(Thy1.2: H-2b/CD45.2+) 1100 cGy CD4+ and CD8+ TCD-BM cells (10×106) with CD4+
Allogeneic (Allo) Balb/C(H-2d/CD45.2+) C57/Bl6(Thy1.2: H-2b/CD45.2+) MHC-I, -II,and miHAs 1100 cGy CD4+ and CD8+ TCD-BM cells (10×106) with CD4+
Model 2. GVHD without Conditioning Regimen
Syngeneic (Syn) C57/Bl6(Thy1.1: H-2b/CD45.2+) C57/Bl6(Thy1.2: H-2b/CD45.2+) None Whole Splenocytes (50×106 cells)
Allogeneic (Allo) C57/Bl6(Thy1.1: H-2b/CD45.2+) B6D2F1(H-2bxd, CD45.2+,Thy1.2+) MHC-I, -II,and miHAs None CD4+ and CD8+ Whole Splenocytes (50×106 cells)

MHC – Major histocompatibility complex.

MiHAs – Minor histocompatibility antigens.