Table 1.
Clinicopathological and laboratory information for patients selected for RT-qPCR analysis
| Parameter | HGSC a , n = 35 | CCC a , n = 19 | |
|---|---|---|---|
| Age; mean ± SD (range) |
64.0 ± 11.3 (45–87) |
63.9 ± 15.3 (28–83) |
|
| Preoperative CA125 (kU/L); mean ± SD |
3023 ± 4129 |
1438 ± 2198 |
|
| FIGO stage |
I |
0 |
10 |
| II |
0 |
3 |
|
| III |
25 |
5 |
|
| IV |
10 |
1 |
|
| Residual disease |
0 cm |
3 |
13 |
| <2 cm |
9 |
4 |
|
| >2 cm |
23 |
2 |
|
| Start of chemotherapy (days after surgery); mean ± SD |
27.7 ± 11.6 |
25.7 ± 13.8 |
|
| CA125 response
b
|
Yes |
31 |
15 |
| No |
1 |
0 |
|
| Optimal CA125 normalization
b
|
Yes |
20 |
13 |
| No |
14 |
3 |
|
| Median time (months) until progression (95% CI) |
10 (7–13) |
NA
c
|
|
| Median time (months) until death (95% CI) |
26 (18–34) |
105 (35–175) |
|
| Status at last follow-up d | NED |
1 |
11 |
| AWD |
1 |
1 |
|
| DOD |
33 |
6 |
|
| DOUC | 0 | 1 | |
a HGSC: High-grade serous ovarian carcinoma; CCC: Clear cell ovarian carcinoma.
b According to the GCIG criteria (http://www.gcig.igcs.org). For HGSC: Two patients who received no postoperative treatment due to poor general condition, one patient with preoperative CA125 < 70; For CCC: One patient who received no postoperative treatment due to poor condition, three patients with preoperative CA125 < 70.
c Could not be calculated since the Kaplan-Meier survival curve stays above 50%.
d NED = No evidence of disease; AWD = Alive with disease; DOD = Dead of disease; DOUC = Dead of unrelated cause.