Table 2.
Differentially expressed miRNAs between HGSC, CCC and OSE of global miRNA expression profiling* selected for RT-qPCR validation
| |
HGSC vs. OSE
a
|
CCC vs. OSE
a
|
CCC vs. HGSC
a
|
|||
|---|---|---|---|---|---|---|
| miRNAs | p-values | FC values | p-value | FC value | p-value | FC value |
|
miR-134 |
8.3 × 10-8 |
-16.7
b
|
|
|
1.0 × 10-4 |
5.8 |
|
miR-141-3p |
1.1 × 10-11 |
46.1 |
2.4 × 10-10 |
34.9 |
|
|
|
miR-182-5p |
6.0 × 10-9 |
30.2 |
1.4 × 10-8 |
32.7 |
|
|
|
miR-200a-3p |
7.3 × 10-10 |
33.6 |
1.3 × 10-9 |
38.8 |
|
|
|
miR-200a-5p |
3.0 × 10-13 |
33.5 |
6.9 × 10-12 |
26.5 |
|
|
|
miR-200b-3p |
1.1 × 10-9 |
29.1 |
2.9 × 10-8 |
21.1 |
|
|
|
miR-200c-3p |
1.2 × 10-12 |
16.5 |
1.2 × 10-11 |
15.0 |
|
|
|
miR-202-3p |
8.0 × 10-6 |
-36.9 |
|
|
2.3 × 10-4 |
16.3 |
|
miR-205-5p |
4.9 × 10-5 |
105.1 |
|
|
3.1 × 10-3 |
-23.1 |
|
miR-383 |
8.2 × 10-12 |
-33.7 |
1.5 × 10-11 |
-38.7 |
|
|
|
miR-424-5p |
2.6 × 10-9 |
-26.0 |
4.0 × 10-6 |
-10.1 |
|
|
|
miR-508-5p |
|
|
4.4 × 10-3 |
11.6 |
3.1 × 10-6 |
75.0 |
|
miR-509-3p |
4.3 × 10-3 |
-10.3 |
|
|
2.6 × 10-6 |
83.4 |
|
miR-509-5p |
|
|
5.6 × 10-4 |
11.4 |
1.8 × 10-6 |
34.0 |
|
miR-509-3-5p |
3.9 × 10-3 |
-10.2 |
|
|
1.9 × 10-6 |
84.6 |
|
miR-510 |
9.3 × 10-3 |
-5.2 |
7.9 × 10-3 |
6.1 |
3.0 × 10-6 |
31.7 |
|
miR-513a-5p |
|
|
4.8 × 10-3 |
7.4 |
4.1 × 10-6 |
33.5 |
| miR-514b-5p | 9.7 × 10-3 | -6.5 | 3.8 × 10-3 | 9.8 | 1.3 × 10-6 | 63.6 |
*Affymetrix GeneChip miRNA 2.0 Arrays. a HGSC: High-grade serous ovarian carcinoma. OSE: ovarian surface epithelium. CCC: Clear cell ovarian carcinoma. b ‘-’ illustrates underexpression. FC: Fold change. P-values are calculated on original data (before FDR corrections).