Skip to main content
. 2014 Feb 18;9(2):e88916. doi: 10.1371/journal.pone.0088916

Figure 1. Curcumin enhances stem cell proliferation of NSC derived from SVZ in low doses, however it induces apoptosis at high doses.

Figure 1

A: Schematic presentation of treatments timeline used in moderate and severe SCI. B: Micropunched area of the subventricular zone (SVZ), depicting the presence of ependymal cells (brown), astrocytes (blue), transit amplifying cells (green) and neuroblasts (red). C: Immunofluorescence analysis demonstrates the presence of stem cell marker nanog in neurospheres and DAPI staining for DNA. D, E: Effect of curcumin on neurosphere formation. At a low concentration of 500 nM, curcumin treatment stimulated proliferation of NSC in 24 hr. At higher concentrations (1 uM), curcumin caused autolysis and neurosphere fragmentation. The chemical structure of curcumin is also displayed.