Table 1. Distribution of mutations with regards to NA subtype.
NA | No. of isolates (x) | Mutation | No. of mutants (y) | % (y/x) |
N1 | R118K | 1 | 2.6 | |
R118K D151N | 1 | 2.6 | ||
R118K D151N D198N | 1 (3) 1) | 2.6 (7.7)4) | ||
D151K | 1 2) | 2.6 | ||
I222V | 1 | 2.6 | ||
All | 39 | 5 | 12,8 | |
N2 | - | 0 | 0.0 | |
All | 77 | 0 | 0.0 | |
N3 | R118K | 1 3) | 4.4 | |
R156K | 1 2) | 8.7 | ||
All | 23 | 3 | 13.0 | |
N5 | R118K R152K D198N | 1 3) | 8.3 | |
All | 12 | 1 | 8.3 | |
N6 | R152K | 6 (2) 3) | 10.9 | |
All | 55 | 6 | 10.9 | |
N8 | - | 0 | 0.0 | |
All | 13 | 0 | 0.0 | |
N9 | R118K | 2 | 13.4 | |
R118K D151N | 1 | 7.7 | ||
All | 11 | 3 | 27.3 | |
Total | 230 | 18 (15) 4) | 7.4 (6.5) 4) |
Mainly adopted from Orozovic et al. [26].
Sum of all R118K mutations.
Mutation unrelated to inhibitor resistance.
Isolates that were not analyzed.
Previously published values.