Table 2.
Sensory analyses of skin irritation
| Formulations and degree of irritation | Time (minutes)
|
||||
|---|---|---|---|---|---|
| 30 | 60 | 90 | 120 | 180 | |
| CH-NC-CP | |||||
| Negligible | 69 | 69 | 92 | 100 | 100 |
| Slight irritation | 23 | 31 | 8 | 0 | 0 |
| Moderate irritation | 8 | 0 | 0 | 0 | 0 |
| Severe irritation | 0 | 0 | 0 | 0 | 0 |
| CH-NC | |||||
| Negligible | 100 | 92 | 100 | 100 | 100 |
| Slight irritation | 0 | 8 | 0 | 0 | 0 |
| Moderate irritation | 0 | 0 | 0 | 0 | 0 |
| Severe irritation | 0 | 0 | 0 | 0 | 0 |
| CH-ET-CP | |||||
| Negligible | 46 | 8 | 15 | 54 | 62 |
| Slight irritation | 46 | 38 | 69 | 31 | 38 |
| Moderate irritation | 8 | 46 | 8 | 15 | 0 |
| Severe irritation | 0 | 8 | 8 | 0 | 0 |
| CH-ET | |||||
| Negligible | 77 | 85 | 92 | 100 | 100 |
| Slight irritation | 23 | 15 | 8 | 0 | 0 |
| Moderate irritation | 0 | 0 | 0 | 0 | 0 |
| Severe irritation | 0 | 0 | 0 | 0 | 0 |
| Commercial formulation | |||||
| Negligible | 8 | 0 | 0 | 38 | 92 |
| Slight irritation | 15 | 8 | 38 | 54 | 8 |
| Moderate irritation | 54 | 23 | 62 | 8 | 0 |
| Severe irritation | 23 | 69 | 0 | 0 | 0 |
Note: Number represents percentages of volunteers who felt slight, moderate, or severe irritation.
Abbreviations: CH, chitosan gel; NC, nanocapsules; CP, capsaicinoids; ET, ethanolic solution.