Table 3.
Skin permeation parameters of capsaicinoids from different semi-solid formulations
| Formulations | AUC0–30 (μg/cm2/hour) | Total amount permeated (μg/cm2) | Lag time (hours) | Flux (μg/cm2/hour) |
|---|---|---|---|---|
| CH-NC-CP | 40.80±12.15a,b | 4.23±0.97a | 9.01±1.04a,b | 0.19±0.04a |
| CH-ET-CP | 343.84±87.54 | 29.41±7.17 | 5.91±0.69 | 1.19±0.29 |
| Commercial formulation | 114.92±16.11 | 9.39±1.34 | 5.34±1.50 | 0.38±0.07 |
Notes:
a
Significant differences (P<0.05) between CH-NC-CP and CH-ET-CP;
b
significant differences (P<0.05) between CH-NC-CP and commercial formulation.
Abbreviations: CH, chitosan gel; NC, nanocapsules; CP, capsaicinoids; ET, ethanolic solution.