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. Author manuscript; available in PMC: 2015 Jan 16.
Published in final edited form as: Cell. 2014 Jan 16;156(0):109–122. doi: 10.1016/j.cell.2013.12.018

Figure 5. Knockdown Foxo in Enterocytes reduces dysbiosis and ISC overproliferation.

Figure 5

A) Age-related changes in gut commensal numbers in foxo loss of function conditions. Intestinal CFUs (averages and SEM) quantified in wild-type, foxoW24 hererozygous, or foxoW24 homozygous sibling animals of the indicated ages. foxoW24 was backcrossed for 5 generations into the y1w1 background (**p<0.01 relative to wild-type).

B–C) Intestinal CFUs (B) and mitotic ISCs (C) quantified from animals of the indicated ages in which Foxo (or Foxo and PGRP-SC2) was knocked down specifically in ECs (using NP1∷Gal4 backcrossed into w1118). Averages and SEM are shown (N>17 for each data point).

D–E) As above, using NP1∷Gal4 backcrossed into the y1w1 background (*p<0.05; **p<0.01).

See also Figure S5.