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. 2014 Feb 19;8:46. doi: 10.3389/fncel.2014.00046

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Copyright © 2014 Garkun and Maffei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The endogenous CB agonist AEA (anandamide) replicated the effect of WIN 55,212-2 on inhibitory neurotransmission. (A) Example traces of sIPSCs in the absence (Control) and in presence of AEA (1 μM). (B) sIPSC traces averaged across 150 events before (black) and during the perfusion of AEA (gray) for the cell shown in (A). (C) Bar plot summarizing the effect of AEA on sIPSC amplitude and frequency. Amplitude and frequency are represented relative to Control to show fold changes. Black: control; white: AEA. (D,E) Cumulative distributions of sIPSC amplitude (D), and frequency (E) in control (black), and in the presence of AEA (gray). Data are presented as mean ± SEM, statistical significance is indicated by * for P < 0.05.