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. 2014 Feb 19;8:46. doi: 10.3389/fncel.2014.00046

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Copyright © 2014 Garkun and Maffei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Repetitive burst firing of layer 4 pyramidal neurons induces endocannabinoid-mediated potentiation of inhibition. (A) Response of pyramidal neuron (Pyr) to the injection of 10 – 3 ms long depolarizing current pulses (Stim). (B) Repetitive burst firing of layer 4 pyramidal neuron (20 bursts of 10 action potentials at 50 Hz repeated at 0.1 Hz) potentiates sIPSC amplitude. The potentiation is prevented by AM281 (1 μM). Stim: application of induction paradigm. (C) Average sIPSCs before (control) and after burst firing in standard ACSF (20*10AP) and in the presence of AM281 (AM + 20*10AP). Traces are from the cell shown in (A). (D) Group data of sIPSC amplitude and frequency before and after burst firing. Black: control; white: 20*10AP; gray: AM + 20*10AP. All data are expressed relative to Control to show fold changes. Data are presented as mean ± SEM, statistical significance is indicated by * for P < 0.05.