Table 4.
Genes of reference H. influenzae strains that are absent in the Hif KR494 genome
| Locus a,b | Gene/function |
|---|---|
| Histidine biosynthesis pathway | |
| HI0468-HI0474* | hisABCDEFGH operon |
| HI0475 | hisIE |
| Other amino acid biosynthesis pathway | |
| HI0607 | Shikimate 5-dehydrogenase, aroE (phenylalanine, tyrosine and tryptophan) |
| HI0737 | Acetohydroxy acid synthase II (valine, leucine and isoleucine) |
| Anaerobic fermentation of L-ascorbate | |
| HI1024-HI1026* | ulaDEF operon |
| HI1027 | Lyx |
| HI1031 | 2,3-diketo-L-gulonate reductase |
| Folate biosynthesis | |
| HI1190* | 6-pyruvoyl tetrahydrobiopterin synthase |
| HI1464 | Dihydropteroate synthase |
| Secondary molybdenum transporter | |
| HI1469 | modA |
| HI1470-HI1472* | molABC |
| HI1473-HI1475 | modD-salX-cysU |
| HI1525 | modA |
| LOS biosynthesis | |
| HI0867-HI0874* | hmg locus (siaA, wbaP, rffG) |
| HI1578 | Glycosyl transferase WcaA |
| HIB_08850c | UDP-glucose--lipooligosaccharide glucosyltransferase |
| Iron and zinc transporter | |
| HIB_07090c, * | Zinc transporter ZitB |
| HI0291 | Periplasmic mercury transport-like protein |
| HI0661 | Hemoglobin-binding protein OapA |
| HI0712 | Hemoglobin-binding protein |
| Other metabolism | |
| HI0053 | Zinc-type alcohol dehydrogenase (fructose and mannose metabolism) |
| HI0692 | Xanthine-guanine phosphoribosyltransferase (purine metabolism) |
| HI1649 | D-lactate dehydrogenase (pyruvate metabolism) |
| Others | |
| HI0584 | Peptidase, aminobenzoyl-glutamate utilization protein |
| HI0947 | Virulence-associated protein C |
| HI1251 | Virulence-associated protein A |
| HI1465 | Cell division FtsH-like protein |
aCDSs of hypothetical proteins and phage products are not included.
bLocus tags are based on the genome of Rd Kw20 unless otherwise is indicated.
cLocus tags are based on the genome of Hib 10810.
*Target single locus or contiguous loci assessed gene distribution studies (Table 6).