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. Author manuscript; available in PMC: 2015 Feb 7.
Published in final edited form as: Neurosci Lett. 2013 Dec 19;560:86–91. doi: 10.1016/j.neulet.2013.12.028

Figure 3.

Figure 3

Therapeutic potency of antibodies generated by epitope vaccines detected by IHC. (A, B, C, D) Antibodies recognized Lewy Bodies (LBs) (A, B) and Lewy Neurites (LNs) (C, D) in DLB, but not in control brain sections. Of note, anti-α-Syn126-140 recognized higher number of LBs and LNs than anti-α-Syn85-99 and anti α-Syn109-126 antibodies. (A) Number of LBs was calculated based on 10× magnification of DLB brain images. (B) Representative images of DLB and non-DLB brains are presented (original magnification 10×, scale bar=100μm). (C) Intensity of LNs was detected based on 10× magnification of DLB brain images. (D) Representative images of DLB brains (original magnification 40×, scale bar = 20μm).