Table 5.

Top Gene-Based Association Results Based on Level of Statistical Significance

Gene	p Value	Best Test	Betaa	SE	CMAFb	No. Variantsc
LDL-EA
PCSK9	1.81 × 10−62	SKAT	–	–	0.0626	22
LDLR	4.9 × 10−10	T1	15.36	2.47	0.0027	28
HDL-EA
APOC3	3.2 × 10−19	T1	11.75	1.31	0.0035	4
ANGPTL4	5.41 × 10−30	SKAT	–	–	0.0283	11
LIPG	2.55 × 10−29	SKAT	–	–	0.0162	12
LPL	5.76 × 10−29	SKAT	–	–	0.0372	10
Triglycerides-EA
APOC3	4.0 × 10−29	T1	−0.41	0.05	0.0036	4
ANGPTL4	2.70 × 10−37	SKAT	–	–	0.0286	11
LPL	1.56 × 10−31	SKAT	–	–	0.037	10
LDL-AA
PCSK9	1.40 × 10−71	SKAT	–	–	0.1295	25
APOE	2.65 × 10−12	SKAT	–	–	0.0205	3
HDL-AA
APOC3	9.5 × 10−12	T1	10.14	1.49	0.0055	4
CETP	7.7 × 10−09	T1	6.18	1.07	0.0065	7
Triglycerides-AA
APOC3	2.9 × 10−19	T1	−0.34	0.05	0.0055	4
APOE	2.26 × 10−18	SKAT	–	–	0.0205	3

Abbreviations are as follows: TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; EA, European ancestry; AA, African ancestry; Beta, effect size; SE, standard error.

^aBeta is in mg/dl units for LDL and HDL and in percent change for triglycerides.

^bCMAF, cumulative minor allele frequency of the variants contributing to the test.

^cNo. variants, number of variants contributing to the test.