Table 6.
Association of Lipid Variants with Coronary Heart Disease
| Gene | Mutation (Substitution) | rsID | Case Frequency | Control Frequency | Odds Ratio | p Value |
|---|---|---|---|---|---|---|
| Ancestry: EA | ||||||
| ANGPTL8 | c.361C>T (p.Gln121∗l) | rs145464906 | 0.29% | 0.27% | 1.023 | 0.985 |
| PAFAH1B2 | c.482C>T (p.Ser161Leu) | rs186808413 | 2.05% | 2.23% | 0.905 | 0.170 |
| Ancestry: AA | ||||||
| PCSK7 | c.1511G>A (p.Arg504His) | rs142953140 | 0.53% | 0.47% | 1.258 | 0.592 |
| COL18A1 | c.331G>A (p.Gly111Arg) | rs114139997 | 3.39% | 3.38% | 0.996 | 0.971 |
Association with CHD was performed in a total of 63,470 EA individuals and 13,772 AA individuals. 14,201 EA and 2,380 AA individuals developed CHD.