Figure 4.

Sensitivity of Calling Rare Alleles as a Function of the Number of Subjects Selected

Programs (solid lines) are as follows: (A) GIGI (local), (B) GIGI (GW), (C) PRIMUS, and (D) ExomePicks. Ad hoc schemes (dashed lines) are as follows: (E) bottom only and (F) bottom and parents. Refer to Figures S3 and S4 for the actual subjects selected. The “bottom and parents” and “bottom-only” designs had the same sensitivity in the first six selected subjects because the subjects selected were the same until the seventh choice.