FIG. 6.

The generation of extracellular complexes with immune activity. As illustrated in this figure, following release of nuclear molecules during cell death, extracellular complexes with immunologically active components can form. These complexes can involve nuclear molecules in concert with each of other as well as with cytokines and pathogen-associated molecular patterns. The existence of multi-component complexes as shown in the circle is hypothetical but consistent with current data. Reproduced with permission from Pisetsky (43). To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars