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. Author manuscript; available in PMC: 2014 Feb 19.
Published in final edited form as: Cell Rep. 2014 Jan 23;6(3):514–527. doi: 10.1016/j.celrep.2013.12.041

Figure 3. Analysis of tumor topology.

Figure 3

Maps showing topologic differences in the distribution of genetically distinct tumor cells based on copy number for 8q24 BAC (A), chromosome 8 CEP (B), and cellular phenotype (C) in three different regions of a luminal A tumor (Patient 1).

(D) Histograms depicting absolute differences in copy numbers for BAC and CEP probe counts regardless of phenotype in all cells or in adjacent cells before and after treatment.

(E) Histograms depicting absolute differences in copy numbers for BAC and CEP probe counts in all cells of the same phenotype or in adjacent cells of the same phenotype before and after treatment. CD44+CD24− and CD44+CD24+ cell subpopulations are not present after treatment.

(F) Fraction of adjacent cells with the same phenotype before and after treatment. Asterisks indicate significant changes. Significance of differences was determined by calculating the homotypic fraction for 100,000 iterations of permutation testing over randomized cellular phenotypes. See also Figure S4, S5, and Table S3.