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Arachidonic acid metabolic pathways. Free arachidonic acid (AA) is formed mainly from the metabolism of membrane phospholipids by phospholipase A2 (PLA2). Free AA is metabolized by cyclooxygenases (COX) to prostaglandins (PGs) and thromboxane (Tx), by lipoxygenases (LOX) to hydroxyeicosatetraenoic acids (HETEs) and leukotrienes (LTs), and by cytochrome P450s (CYP) to HETEs and epoxyeicosatrienoic acids (EETs).
