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Cyclooxygenase pathway of AA. Cyclooxygenase active site of COX converts AA to PPG2 and peroxidase active site of COX converts PGG2 to PGH2. Then, specific prostaglandin synthases or isomerases convert PGH2 to their corresponding PGI2, PGD2, PGE2, PGF2α, PGJ2, and TxA2. In prostate cancer, PGI2 and PGD2 are antitumorigenic while PGE2 and TxA2 are tumorigenic.
