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. Author manuscript; available in PMC: 2014 Feb 19.
Published in final edited form as: Future Lipidol. 2008 Aug 1;3(4):453–467. doi: 10.2217/17460875.3.4.453

Figure 3.

Figure 3

Lipoxygenase pathway of AA. LOX metabolizes AA to their corresponding isomeric hydroperoxyeicosatetraenoic acids (HPETEs). 5-HPETE is reduced by peroxidase to 5-HETE, then, 5-HETE is converted to 5-oxo-eicosatetraenoic acid (5-oxo-ETE). 5-HETE and 5-ox-ETE are tumorigenic. Role of 8-HETE in prostate cancer is not known while 12-HETE is tumorigenic. 15-LOX-1 metabolizes the major substrate, linoleic acid (LA) to 13-hydroxyoctadecadienoic acid (13-HODE) (inset). 15-LOX-1 is tumorigenic. 15-LOX-2 metabolizes AA to 15-HETE, which is antitumorigenic in prostate cancer.