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Structure of the core Ψ-packaging domain of HIV-1. Schematic representation of the in vitro biophysical assay. Attached to the 5′ and 3′ ends of stem loop 3 (SL3) are the TET fluorophore and blackhole quencher (BHQ1), respectively, which form a destabilization assay in the presence of Gag. Small molecules that inhibit the destabilation of SL3 are taken forward, after validation, to a viral replication assay.
