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Biological activity of NSC260594. (A) 24 h postinfection the expression of β-galactosidase within the TZM-bl cell were imaged using X-Gal (blue spots in images). (B) Viability of the 293T cells (blue line, 50% inhibition (CC(50) = N/A)), viral production from transfected 293T (green line, 50% inhibition (p24(50) = 11.3 ± 3.4 μM)) and infectivity of harvested viral particles (red line 50% inhibition (IC(50) = 4.5 ± 1.8 μM)) in the presence of different concentrations of NSC260594.
