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Dendogram showing the 61 human proteins predicted to have both a BTB domain and kelch repeats. The red (underlined) proteins have been shown to act as substrate adaptors for the Cul3-based E3 ligase. The length of the lines connecting the proteins is related to the degree of homology, with shorter distances meaning more closely related (higher percentage of homology). A color version of this figure is available online at www.landesbioscience.com/curie.
