Figure 3.

Immunofluorescence microscopy of the cerebral cortex from Lmna^plao/plao (PLAO/PLAO), Lmna^{plao-5nt/plao-5nt} (5NT/5NT), Lmna^{plao-utr/plao-utr} (UTR/UTR) and wild-type (WT) littermate mice, revealing increased lamin A expression in the mice harboring mutations in prelamin A's 3′ UTR. (A and B) Low- and high-magnification images of the cerebral cortex stained with antibodies against lamin A (green) and lamin B1 (red). The scattered lamin A-positive cells in wild-type and Lmna^plao/plao mice are endothelial cells (5). Scale bar in (A), 100 µm; (B), 20 µm.