Table 1. Frequency analysis of Vpr variants from long-term nonprogressor (LTNP) and rapid progressor (RP) subjects.
| Residue no. | Amino acid in NL43 (WT) | Amino acid (frequency, %) | Magnitude Δp | |
| LTNP (n = 192)* | RP (n = 102)* | |pLTNP−pNP/RP| | ||
| 3 | Q | H (2.54), R (4.57) | Absent | 0.073 |
| 16 | N | H (5.58) | Absent | 0.055 |
| 19 | T | A (24.48) | Absent | 0.281† |
| 28 | S | T (7.65) | Absent | 0.204† |
| 32 | R | K (18.87) | K (2.96) | 0.149† |
| 36 | R | Absent | W (17.64) | 0.156† |
| 37 | I | L (15.3), V (12.2) | Absent, V (41.16) | 0.02 |
| 42 | L | Absent | F (2.94) | 0.024 |
| 55 | A | Absent, T (32.64) | V (4.9), T (20.58) | 0.065 |
| 63 | I | Absent, T (3.06) | S (6.86), T (31.36) | 0.265† |
| 68 | L | Absent | M (15.68) | 0.157† |
| 84 | T | S (0.51) | S (12.74) | 0.326† |
| 85 | R | Absent | Y (6.36) | 0.083 |
| 86 | Q | R (33.66), absent | R (5.88), P (9.8) | 0.183† |
| 87 | R | G (4.59) | Absent | 0.08 |
| 88 | R | P (14.28), T (4.98), G (0.51) | Absent, absent, G (4.9) | 0.149† |
| 89 | A | R (23.97) | R (4.9) | 0.222 |
| 90 | R | N (18.36), A(4.59) | Absent, absent | 0.266† |
| 91 | N | R (6.59), G (13.77) | R (34.3), absent | 0.202† |
| 94 | S | R (22.44), A (7.68) | Absent, A (34.3) | 0.014 |
| 96 | S | R (4.59) | R (35.28) | 0.264† |
Sequences were obtained from the HIV sequences database at Los Alamos National Laboratories.
*
The number of sequences (n) for each group (LTNP and RP) is indicated.
†
Significance was assessed by Bonferroni analysis using the magnitude Δp.