Table 3.

Age-related changes in the incidences of macroscopic findings at necropsy and microscopic lesions in WH rats at PND 7–14

		PND
		7	8	9	10	11	12	13	14
Total no. of litters examined		4	4	4	3	4	3	4	4
Total no. of pups examined		39	27	38	33	26	31	38	36
% of litters with pups with any macroscopic lesion		100.0	100.0	100.0	100.0	100.0	66.7	100.0	100.0
% of pups with any macroscopic lesion		33.3	63.0	52.6	60.6	65.4	45.2	47.4	27.8
% of pups with ring-shaped red region in the anterior ocular segment		12.8	37.0	39.5	45.5	50.0	35.5	13.2	2.8
% of pups with red spots in the posterior ocular segment		20.5	29.6	26.3	21.2	23.1	16.1	39.5	25.0
% of litters with pups with any microscopic lesion		100.0	100.0	100.0	100.0	100.0	100.0	100.0	100.0
% of pups with any microscopic lesion		64.1	33.3	55.3	57.6	80.8	64.5	50.0	50.0
% of pups with deposition of erythrocytes in the trabecular meshwork	Total	25.6	18.5	55.3	54.5	57.7	54.8	20.7	19.4
	+	10.3	7.4	28.9	9.1	34.6	25.8	17.2	19.4
	2+	7.7	7.4	15.8	18.2	19.2	29.0	3.4	0.0
	3+	7.7	3.7	10.5	27.2	3.8	0.0	0.0	0.0
% of pups with accumulation of erythrocytes in the aqueous chamber	Total	23.1	18.5	39.5	51.5	38.5	41.9	20.7	25.0
	+	7.7	0.0	21.1	15.2	30.8	29.0	13.8	22.2
	2+	7.7	11.1	13.2	18.2	7.7	12.9	6.9	2.8
	3+	7.7	7.4	5.3	18.2	0.0	0.0	0.0	0.0
% of pups with retinal hemorrhage		30.8	14.8	7.9	9.1	19.2	6.5	31.0	13.9
% of pups with choroidal hemorrhage		5.1	0.0	2.6	0.0	0.0	0.0	0.0	8.3
% of pups with vitreal hemorrhage		15.4	7.4	0.0	3.0	0.0	0.0	0.0	5.6