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. Author manuscript; available in PMC: 2015 Jan 15.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Nov 28;24(2):674–678. doi: 10.1016/j.bmcl.2013.11.049

Table 2.

SAR of the 3-cyanophenyl group of NS9283

Compound Structure PAM(Y or N)a EC50 (uM) Emaxb
4a graphic file with name nihms551756t6.jpg N — —
4b graphic file with name nihms551756t7.jpg N — —
4c graphic file with name nihms551756t8.jpg N — —
4d graphic file with name nihms551756t9.jpg N — —
4e graphic file with name nihms551756t10.jpg N — —
4f graphic file with name nihms551756t11.jpg Y 1.3±0.4 1.2
4g graphic file with name nihms551756t12.jpg N — —
4h graphic file with name nihms551756t13.jpg Y 0.69±0.35 1.2
4i graphic file with name nihms551756t14.jpg Y 1.7±0.5 0.81
4j graphic file with name nihms551756t15.jpg N — —
4k graphic file with name nihms551756t16.jpg N — —
4l graphic file with name nihms551756t17.jpg N — —
4m graphic file with name nihms551756t18.jpg Y 1.0±0.3 0.98
a,b

See Table 1 caption.