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. Author manuscript; available in PMC: 2015 Jan 15.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Nov 28;24(2):674–678. doi: 10.1016/j.bmcl.2013.11.049

Table 4.

SAR of 2,5-disubstituted tetrazole analogs

Compound Structure PAM(Y or N)a EC50 (uM) Emaxb
5k graphic file with name nihms551756t30.jpg Y 2.0±0.9 2.5
11a graphic file with name nihms551756t31.jpg N — —
11b graphic file with name nihms551756t32.jpg N — —
11c graphic file with name nihms551756t33.jpg N — —
11d graphic file with name nihms551756t34.jpg N — —
11e graphic file with name nihms551756t35.jpg N — —
11f graphic file with name nihms551756t36.jpg N — —
11g graphic file with name nihms551756t37.jpg N — —
11h graphic file with name nihms551756t38.jpg N — —
a,b

See Table 1 caption.