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. Author manuscript; available in PMC: 2015 Jan 15.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Nov 28;24(2):674–678. doi: 10.1016/j.bmcl.2013.11.049

Table 5.

SAR of 3-pyridinyl tetrazole analogs

Compound Structure PAM(Y or N)a EC50 (uM) Emaxb
12a graphic file with name nihms551756t39.jpg N — —
12b graphic file with name nihms551756t40.jpg N — —
12c graphic file with name nihms551756t41.jpg N — —
12d graphic file with name nihms551756t42.jpg N — —
12e graphic file with name nihms551756t43.jpg N — —
12f graphic file with name nihms551756t44.jpg Y 2.2±0.4 0.96
12g graphic file with name nihms551756t45.jpg N — —
12h graphic file with name nihms551756t46.jpg Y 0.7±0.12 1.9
12i graphic file with name nihms551756t47.jpg N — —
12j graphic file with name nihms551756t48.jpg N — —
a,b

See Table 1 caption.