Table 2.
Mouse microsome stability and CYP450 inhibition results.
| Compound | Mouse microsome stability (min) |
NADPH- dependent |
CYP3A4 % inhibition (10 µM) |
CYP2D6 %inhibition (10 µM) |
|---|---|---|---|---|
| 10 | 46 | Y | 61 | 51 |
| 19 | 42 | Y | 34 | 24 |
| Torin1 | 1.3 | N | ND | ND |
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