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. Author manuscript; available in PMC: 2014 Feb 19.
Published in final edited form as: Bioorg Med Chem Lett. 2011 May 7;21(13):4036–4040. doi: 10.1016/j.bmcl.2011.04.129

Table 4.

Ambit and Invitrogen profiles of compound 10 against PIKKs

Kinase symbol Invitrogen IC50 (nM) Ambit score (%)
PI4Kα >10000 ND
PI4Kβ 3440 ND
PI3K-C2α 1110 ND
PI3K-C2β 437 0.65
hVPS34 170 ND
P110α/P85α 922 0.1
P110δ/P85α 1170 2
P110γ 1170 0.05
mTOR 3.01 0