Table 1.

Studies published since January 2009 meeting the original inclusion criteria (37).

Reference	Question that can be addressed regarding the effects of SSBs on weight	How meta-analyzed	Primary Outcome(s) and Analysis as Stated in Trials Registry and Paper
Njike et al., 2011 (30)	Added two servings per day of sugar-free cocoa, sugared cocoa, or placebo cocoa in obese adults in a crossover trial, six weeks each phase.	Meta-analyzed all response data for all phases (author provided raw data on request) – combined both caloric groups (sugared cocoa and placebo cocoa) and subtracted sugar-free group.	Trial Registry: NCT00538083. Primary - Endothelial function Secondary - Blood pressure, lipid profile, low-density lipoprotein (LDL) oxidation, lipid hydroperoxide, C-reactive protein (CRP), glucose, body weight, waist circumference, endothelin Paper: Primary - Endothelial function Secondary - Blood pressure, lipid profile and fasting glucose, food intake, endothelin, CRP, oxidized LDL, lipid hydroperoxide, anthropometric measures (body weight, body mass index (BMI), waist circumference) Missing Data Handling: Intention to treat analysis
Vaz et al., 2011 (36)	Added choco-malt beverage mix to water and gave one serving per day to children in a parallel trial.	Meta-analyzed untreated control group versus unfortified group.*	Trial Registry: NCT00876018 Primary - Physical fitness and performance Secondary - Nutritional status, muscle strength and endurance Paper: Primary – Within participant change in physical performance: whole-body endurance, aerobic capacity, speed and visual reaction time Secondary – Nutritional status, muscle strength, endurance in forearm flexor muscle group Missing Data Handling: Complete case analysis
Maersk et al., 2012 (34)	Added 1 liter per day of milk, regular cola, diet cola, or water in overweight/obese adults in a parallel trial for six months.	Meta-analyzed regular cola group versus diet group.	Trial Registry: NCT00777647 Primary - Body weight, magnetic Resonance spectroscopy, magnetic resonance imaging, dual-energy x-ray absorptiometry scan Secondary - Circulating metabolic parameters, blood pressure Paper: Primary - intrahepatic fat and intramyocellular fat Secondary - fat mass, fat distribution, metabolic risk factors Missing Data Handling: complete case analysis except for two cases who dropped out at 5 months, for whom last observation was carried forward
Ebbeling et al., 2012 (33)	Multi-component program to reduce/replace SSBs with noncaloric beverages in adolescents.	Meta-analyzed weight change at end of one-year intervention period.	Trial Registry: NCT00381160 Primary - BMI change at two years Secondary – none stated Paper: Primary – Change in mean BMI at two years (one year post-intervention) Secondary – differences between ethnicities, change in body fat as a percentage of total weight Missing Data Handling: Imputed - baseline and last observation carried forward in separate analyses
de Ruyter et al., 2012 (29)	Provided school children identically labeled SSB or non-caloric equivalent to consume one can/day.	Considered an SSB reduction study as inclusion criteria was current SSB consumers.	Trial Registry: NCT00893529 Primary - BMI Z-score at 6, 12, and 18 months Secondary – Body composition using skinfolds, bioelectrical impedance analysis (BIA), waist-to-height ratio, dental health, sensory evaluation (satiety and liking of study drink) Paper: Primary - Z-score of BMI for age at 18 months. Secondary – (all pre-specified) waist-to-height ratio, sum of the four skinfold thickness measurements, and fat mass (BIA). Additional outcomes were weight, height, z score for height, waist circumference, and weight change adjusted for height change Missing Data Handling: multiple imputation and complete case analysis
Tate et al., 2012 (35)	Substituted SSBs with artificially sweetened equivalent or water in obese adults who drink two or more servings per day at baseline.	Meta-analyzed water and artificially sweetened groups together versus SSB group.	Trial Registry: NCT01017783 Primary – Weight change at 3 and 6 months Secondary - urine specific gravity, fasting glucose Paper: Primary - Weight change at 6 months. Secondary - compare the non-caloric beverage groups with the control group on criterion measures of weight loss, waist circumference, blood pressure, glucose, and osmolality from 0 to 3 and 0 to 6 months Missing Data Handling: Multiple imputation for continuous variables, complete cases for 5% weight loss criterion analysis

SSB – Sugar-sweetened Beverage

^*We originally excluded any types of beverages that had growth promotion as a function, but the unfortified beverage met our original inclusion criteria and is included in this analysis.