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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Pharmacol Biochem Behav. 2013 Dec 5;117:17–24. doi: 10.1016/j.pbb.2013.11.026

Figure 4.

Figure 4

Effect of MAGL inhibitor on stress-induced serum corticosterone concentrations. Zero minutes represents the offset of restraint; mice were treated with vehicle or 16 mg/kg JZL184 30 minutes prior to the beginning of the restraint period. (A) Male wild type mice; two way ANOVA results: time (F5,171 = 21, p<0.0001), treatment (F1,171 = 0.25, n.s.) and interaction (F5,171 = 4.4, p<0.001). (B) Female wild type mice; two way ANOVA results: time (F5,169 = 23, p<0.0001); treatment (F1,169 = 0.03, n.s.) and interaction (F5,169 = 1.7, p=0.14). (C) Male CB1R−/− mice; two-way ANOVA results: time (F5,110 = 28, p<0.0001); treatment (F1,110 = 0.21, n.s.) and interaction (F5,110 = 0.58, n.s.) (D) Female CB1R−/− mice; two way ANOVA time (F5,129 = 25, p<0.0001), treatment (F1,129 = 0.9, n.s.) and interaction (F5,129 = 0.2, n.s.). #p<0.05, ##p<0.01; significantly different by Holm-Šídák t tests. Sample size is 17 – 35 per group at the −30 and 0 minute time points and 3– 12 per group at each of the other time points.