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In vitro production of KYNA from d-KYN and l-KYN in rat forebrain and liver: effect of AOAA. Tissue homogenates (n = 3 per group) were incubated for 2 h at 37°C with 100 µM d-KYN or l-KYN in the absence or presence of AOAA (1 mM). Data are the mean ± SEM
| KYNA (pmoles/h/mg tissue) | d-KYN | d-KYN + AOAA | % inhibition | l-KYN | l-KYN + AOAA | % inhibition |
|---|---|---|---|---|---|---|
| Forebrain | 0.26 ± 0.01 | 0.03 ± 0.01 | 88.1 | 67.52 ± 4.07 | 0.26 ± 0.03 | 99.6 |
| Liver | 22.76 ± 3.79 | 0.46 ± 0.19 | 97.7 | 1635.27 ± 217.81 | 18.55 ± 0.32 | 98.8 |
