Figure 2. Effects of the combination of favipiravir and oseltamivir on lung virus titers (log₁₀ 50% cell culture infectious doses/g) during an influenza A/California/04/2009 (H1N1pdm) virus infection in mice.

Oral gavage treatments were administered twice a day for 5 days starting 4 h after virus exposure. Viral titers were determined from lungs harvested on day 3 (A & B) and day 6 (C & D). mg/kg/day doses are given in parentheses. This study ran concurrently with that of Table 2.

*p < 0.05; **p < 0.01; ***p < 0.001, compared with placebo.

Favi: Favipiravir; Oselt: Oseltamivir.