Table 1.
Compound (mg/kg/day) | Oseltamivir (3) | Oseltamivir (1) | Oseltamivir (0.3) | Oseltamivir (0.1) | Oseltamivir (0) |
---|---|---|---|---|---|
Favipiravir (30) | 10/10*** (>21) | 6/10** (9.3 ± 2.6) | 4/10* (7.8 ± 1.2) | 4/10* (8.0 ± 0.9) | 1/10 (7.4 ± 1.3) |
Favipiravir (10) | 9/10*** (9.0) | 3/10* (8.4 ± 1.3) | 2/10 (8.1 ± 1.9) | 1/10 (7.8 ± 0.8) | 0/10 (6.9 ± 0.9) |
Favipiravir (3) | 8/10*** (9.5 ± 2.1) | 3/10* (9.7 ± 2.0) | 2/9 (8.9 ± 2.5) | 1/10 (8.0 ± 1.1) | 0/10 (8.0 ± 1.6) |
Favipiravir (1) | 7/10*** (8.7 ± 1.2) | 3/10* (8.4 ± 1.7) | 4/10* (6.7 ± 1.2) | 1/10 (7.6 ± 1.1) | 0/10 (6.7 ± 1.1) |
Favipiravir (0) | 5/10** (7.8 ± 0.8) | 4/10* (7.2 ± 0.8) | 4/10* (7.2 ± 1.3) | 1/10 (7.0 ± 0.9) | 1/20 (6.5 ± 0.6) |
Results are demonstrated as survivors/total (mean day of death of mice that died during the 21-day observation period ± standard deviation). The mean day of death test is statistically analyzed only for mice that die. Mean without standard deviation data means only one mouse died. >21 indicates that all of the mice lived through the end of the experiment.
p < 0.05;
p < 0.01;
p < 0.001, compared with placebo.