Table 2.

Follow-up experiment demonstrating the effects of oral gavage administration of favipiravir and oseltamivir, either alone or in combination, on the survival of mice inoculated with pandemic influenza A/California/04/2009 (H1N1pdm) virus.

Compound (mg/kg/day)	Oseltamivir (3)	Oseltamivir (1)	Oseltamivir (0)
Favipiravir (100)	10/10*** (>21)	10/10*** (>21)	10/10*** (>21)
Favipiravir (30)	9/10*** (9.0)	10/10*** (>21)	4/10* (9.0 ± 2.9)
Favipiravir (10)	10/10*** (>21)	9/10*** (10.0)	3/10* (8.1 ± 1.3)
Favipiravir (0)	8/10*** (6.5 ± 0.7)	6/10** (8.3 ± 1.0)	0/10 (6.8 ± 0.9)

Results are demonstrated as survivors/total (mean day of death of mice that died during the 21-day observation period ± standard deviation). The mean day of death test is statistically analyzed only for mice that die. Mean without standard deviation data means only one mouse died. >21 indicates that all of the mice lived through the end of the experiment.

^*p < 0.05;

^**p < 0.01;

^***p < 0.001, compared with placebo.