Table 3.

Effects of oral gavage administration of favipiravir and oseltamivir, either alone or in combination, on the survival of mice inoculated with influenza A/Mississippi/03/2001 (H1N1) H274Y (oseltamivir-resistant) virus.

Compound (mg/kg/day)	Oseltamivir (100)	Oseltamivir (50)	Oseltamivir (25)	Oseltamivir (0)
Favipiravir (100)	–†	–†	–†	10/10**
Favipiravir (50)	10/10**	10/10**	10/10**	10/10**
Favipiravir (25)	9/10** (10.0)	10/10**	10/10**	6/10** (9.25 ± 2.9)
Favipiravir (12.5)	6/10** (11.5 ± 1.3)	10/10**	2/10 (10.0 ± 0.8)	0/10 (10.0 ± 2.9)
Favipiravir (0)	3/10* (11.7 ± 1.4)	0/9 (9.4 ± 1.6)	0/10 (9.4 ± 0.5)	0/10 (8.7 ± 0.9)

Results are demonstrated as survivors/total (mean day of death of mice that died during the 21-day observation period ± standard deviation). Mean without standard deviation data means only one mouse died.

^*p < 0.01;

^**p < 0.001, compared with placebo.

^†Not determined.