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. 2014 Jan 9;6:15–27. doi: 10.2147/BCTT.S43764

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© 2014 Chatterjee and McCaffrey. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Potential mechanisms by which normal epithelial organization can be lost early in the progression of breast cancer.

Notes: The model on the left shows a cell undergoing EMT to migrate out of the epithelial plane, then reverting through a MET. In the middle model, the epithelial cells rearrange so that they are multilayered. The model at the right shows a cell division perpendicular to the epithelial plane would give rise to a multilayered duct.

Abbreviations: EMT, epithelial-mesenchymal transition; MET, mesenchymal-epithelial transition.