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. 2014 Jan 9;6:15–27. doi: 10.2147/BCTT.S43764

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© 2014 Chatterjee and McCaffrey. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Signaling pathways regulated by apical–basal polarity complexes.

Notes: The polarity complexes impinge upon different signaling pathways. Loss or disruption of normal function of polarity proteins during tumorigenesis correspondingly deregulates the normal function of these pathways and processes, by stimulating their activation or inhibiting them.

Abbreviations: Bim, Bcl-2 interacting mediator of cell death; Crb, Crumbs 3; c-Jun, cellular Jun; ECM, extracellular matrix; HER2, human epidermal growth factor receptor 2; Jak, Janus kinase; JNK, c-Jun N-terminal kinase; Lkb1, liver kinase b1; MAPK, mitogen activated protein kinase; MMP, matrix metalloproteinase; PI3K, phosphatidylinositide 3-kinase; RhoA, Ras homolog gene family member A; Scrib, Scribble; Stat, signal transducer and activator of transcription; TGF, transforming growth factor.