Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jan 9;6:15–27. doi: 10.2147/BCTT.S43764

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Chatterjee and McCaffrey. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

Regulation of Hippo-Yap1/Taz signaling by polarity complexes. The apical Crumbs and lateral Scrib complexes can sequester Yap1/Taz and the Hippo pathway kinases to prevent proliferation in polarized epithelial cells (left). Loss of polarity inactivates the Hippo pathway and releases Yap1/Taz to enter the nucleus to regulate proliferation (right). The Crumbs complex can also regulate SMADs to sensitize cells to epithelial-mesenchymal transition.

Abbreviations: Amot, angiomotin; Crb, Crumbs; EMT, epithelial-mesenchymal transition; Lats, large tumor suppressor; Mst, mammalian STE20-like protein kinase; NF, neurofibromin 2; Patj, Pals1-associated tight junction protein; Scrib, Scribble; Taz, transcriptional coactivator with PDZ binding motif; Yap, Yes-associated protein.