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. Author manuscript; available in PMC: 2014 Feb 19.
Published in final edited form as: J Mol Neurosci. 2009 Aug 19;40(0):204–210. doi: 10.1007/s12031-009-9235-2

Figure 3.

Figure 3

Galantamine (3 mg/kg; a) but not donepezil (2 mg/kg; b) blocks the reduction in extracellular glutamate caused by the local perfusion of kynurenine (2.5 µM; bar) in the PFC. Neither of the two drugs, injected i.p. (arrows), affected the de novo formation of KYNA from kynurenine. KYNA and glutamate were measured in the same microdialysates. Data are the mean ± standard error of the mean of four (a) and six (b) animals, respectively. a, b p<0.05 compared to the respective baseline values (one-way ANOVA)