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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Anesthesiology. 2013 Dec;119(6):1474–1489. doi: 10.1097/ALN.0000000000000022

Figure 6. Paneth cells and intestinal Mast cells release potent effectors to regulate local injury and systemic inflammation following intestinal ischemia/reperfusion.

Figure 6

Most prominently, the Paneth cell-dependent pathway (blue) depends on release of interleukin (IL)-17 from Paneth cells localized at the base of small intestinal crypts. Mast cell responses (purple) use a number of pre-formed and de novo-synthesized products such as proteases (tryptase, mast cell protease (MCP)4), lipid mediators (leukotriens, prostaglandins) and cytokines (tumor necrosis factor (TNF)-α, IL-6).