Figure 5.
H&E tissue sections of MAD109 tumors. Representative sections from mice receiving (A) no pretreatment, (B) VP-16 (30 mg/kg) 2 days prior, (C) VP-16 (30 mg/kg) 3 days prior, and (D) VP-16 (30 mg/kg) 5 days prior to receiving 64Cu-Sar-chTNT-3. Mice were sacrificed 1 day later and tumors were stained with H&E. The largest areas of necrosis from each section are shown on the right at 40× magnification, with areas of necrosis outlined in black.