Table 1. Interaction of RNA aptamer AIR-3A and single nucleotide variants with Hyper-IL-6.
| RNA | Sequence | Kd value [nM] | RNA | Sequence | Kd value [nM] |
|---|---|---|---|---|---|
| AIR-3A | GGGGAGGCUG UGGUGAGGG | 23.1 ± 4.0 | U11A | GGGGAGGCUG AGGUGAGGG | 130.9 ± 47.4 |
| G1U | UGGGAGGCUG UGGUGAGGG | 29.6 ± 4.6 | G12U | GGGGAGGCUG UUGUGAGGG | n. d. |
| G2U | GUGGAGGCUG UGGUGAGGG | n. d. | G13U | GGGGAGGCUG UGUUGAGGG | n. d. |
| G3U | GGUGAGGCUG UGGUGAGGG | 109.0 ± 43.0 | U14A | GGGGAGGCUG UGGAGAGGG | 54.4 ± 11.3 |
| G4U | GGGUAGGCUG UGGUGAGGG | n. d. | G15U | GGGGAGGCUG UGGUUAGGG | n. d. |
| A5U | GGGGUGGCUG UGGUGAGGG | 101.1 ± 76.6 | A16U | GGGGAGGCUG UGGUGUGGG | 86.9 ± 19.5 |
| G6U | GGGGAUGCUG UGGUGAGGG | n. d. | G17U | GGGGAGGCUG UGGUGAUGG | n. d. |
| G7U | GGGGAGUCUG UGGUGAGGG | n. d. | G18U | GGGGAGGCUG UGGUGAGUG | n. d. |
| C8A | GGGGAGGAUG UGGUGAGGG | 24.1 ± 12.8 | G19U | GGGGAGGCUG UGGUGAGGU | n. d. |
| U9A | GGGGAGGCAG UGGUGAGGG | 42.7 ± 13.7 | –G19 | GGGGAGGCUG UGGUGAGG | n. d. |
| G10U | GGGGAGGCUU UGGUGAGGG | n. d. |
n.d. none determinable.