Figure 5. Location of the antigenic regions recognized by immunoenhancing and immunoregulatory antibodies on mouse IL-2. The predicted 3D structure of mIL-2 is represented in white as a cartoon with semi-transparent surface. Residues belonging to functional epitopes are labeled. The functional epitope recognized by the immunoregulatory antibody JES6-1A12 is colored red. Residues contributing to the formation of the overlapping epitopes recognized by the immunoenhancing antibodies JES6-5H4 and S4B6 are highlighted in orange, while additional residues involved only in recognition by JES6-5H4 mAb are shown in blue. The figure was generated with Pymol.